Anti-HMGB1 Chicken IgY Neutralizing Polyclonal Antibody
- Quantity / Tests
- 1 mg
- Species / Antigen
- human, rabbit, bovine, pig, rat, mouse
- Host
- Chicken
- Type
- Polyclonal
- Purification
- salt precipitation
- Regulatory Status
- RUO
HMGB1 and HMGB2 are chromatin-associated nuclear proteins that play an important role in transcription and DNA recombination. HMG proteins contain a highly acidic C-terminal domain as well as two evolutionarily conserved high mobility group (HMG) box motifs as their N-terminus. HMG boxes are found in numerous DNA binding proteins and transcription factors and allow HMG proteins to bind and to bend DNA. Especially, HMGB1 is known as amphoterin, it mediates neurite outgrowth, and it binds receptors for advanced glycation end products (RAGE). Recently, HMGB1 was unexpectedly identified as a cytokine through studies of endotoxemia and sepsis
The antibody recognizes human, rabbit, bovine, pig, rat, and mouse HMGB1, and also recognizes HMGB2 slightly. The specificity of the antibody was confirmed by western blot analysis. Purified pig thymus HMGB1 was used as an immunogen. The antibody was purified from egg yolk by salt precipitation..
Our Product Families
Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms.
All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use.
All of our assays have been designed and manufactured to meet the highest global regulatory requirements and quality standards. Tecan is certified under ISO 9001:2015, ISO 13485:2016 and is audited by a notified body according to Medical Device Single Audit Program (MDSAP).
This is who we are.
As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.
Our range of high-quality immunoassays is supported by a diverse portfolio of automated solutions, making us the perfect partner for you and your customers.
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At Tecan, we are driven to improve people’s lives and health.