FinTest TM IgG4 Screen 90 ELISA

FinTest TM IgG4 Screen 90 ELISA

Enzyme immunoassay (microtiter strips) for the quantitative determination of IgG4 antibodies against 90 food allergens in human serum and plasma.

Lucretius once said that one man’s food may be another man’s poison. Individuals with allergies and other 
types of food sensitivities react adversely to certain foods and food ingredients that others can consume with 
no problems. Many different types of reactions are involved in these individual adverse reactions. Adverse 
food reactions may include IgE and non-IgE-mediated primary immunological sensitivities, non 
immunological intolerances (such as an enzyme deficiency or reactions to certain chemicals), as well as 
secondary sensitivities. 
Adverse immune reactions to foods which are not IgE mediated are often called food “intolerances.” The 
absence of IgE does not make them any less real; instead, other immune mechanisms, such as IgG or IgG4
antibodies are involved. IgG or IgG4-mediated adverse reactions to food are characterized by less severe 
reactions, are much more common (affecting approx. 45 % of the population) and have delayed onset (2 to 
72 hours) after ingestion of an offending substance. Avoiding ingestion of such food (exclusion or rotation 
diet) is the best treatment to decrease symptoms. 
There are several evidences for the involvement of IgG or IgG4 in food „intolerances“ e.g.:
• Allergic reactions may occur independently of antigen-specific IgE
• Subsequent decrease of IgG when the offending food is removed from the diet
• Specific serum IgG has been reported in cases of celiac disease, dermatitis, or atopic eczema, as well as 
in diseases with increased intestinal permeability, and inflammatory bowel disease (IBD)
This evidence leads to the recommendation that IgG or IgG4-specific testing should be considered in cases 
where the patient shows unclear and chronic disorders and in cases where classical diagnostics show no 
evidence.

Distributed by Tecan, IBL International GmbH.

For concrete data please consult the Instruction for Use in the download box on the top right side.