IP-10 / CXCL10 (mouse) ELISA
- Regulatory Status
- RUO
- Kit size
- 12 x 8
- Method
- ELISA
- Incubation time
- 1 x 2h, 1 x 1h, 1 x 10min.
- Standard range
- 7.8 - 500 pg/ml
- Specimen / Volumes
- 50µl serum, plasma, cell culture supernatant
- Substrate / isotope
- TMB 450 nm
IP-10 is a member of the CXC subfamily of chemokines expressed by monocytes. It plays a pivotal role in immune system development and deployment. The Interferon-gamma inducible protein -10kD (IP-10) displays pleiotropic functions including stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. Through this inhibitory effect on neovascularization IP-10 exhibits anti-tumoral effects. It shares a common receptor, CXCR3, with the chemokine MIG, but has been shown to play a distinct role in host defense in infections. IP-10 is further involved in allergic contact dermatitis reactions and other allergic diseases. It appears during immune-mediated processes, in inflammation of the nervous system and in Alzheimer's disease. Its involvement in the regulation of fibroproliferation following inflammatory lung injury has been described.
Synonyms: Interferon-gamma-inducible protein 10, CXCL10
For concrete data please consult the Instruction for Use in the download box on the top right side.
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Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
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