The sInterleukin-2-Receptor ELISA is intended for the quantitative determination of human soluble IL-2 receptor (sIL-2R) in serum and plasma (EDTA, citrate, heparin).
The sInterleukin-2-Receptor ELISA is a solid phase enzyme-linked immunosorbent assay (ELISA), based on the on the sandwich principle measured on an absorbance reader. The assay is semi-automated requiring general purpose laboratory instruments and consumables such as absorbance microplate reader/washer, vortexer and pipettes to execute the test.
The test kit is intended for manual use and can be adapted to different ELISA processors like EVOlyzer®.
The interleukin-2 receptor (IL-2R) is a monomeric, heterodimeric or -trimeric protein¹ expressed on the surface of certain immune cells like lymphocytes that binds and responds to a cytokine called IL-2². Interleukin-2 (IL-2) is a body own signaling molecule mainly produced by activated T-cells. It acts on different types of B- and T-cells via the Interleukin-2 Receptor. The functional Interleukin-2 Receptor consists either of two or three protein chains. The dimeric IL-2R consists of the IL-2Rβ (CD122) chain and the IL-2Rγ (CD132) that form an intermediate affinity receptor for IL-2. If the IL-2α (CD25) chain is incorporated into the receptor complex the IL-2R attains high affinity for IL-2¹.
In 1985 the soluble Interleukin-2 Receptor (sIL-2R, sCD25, sTAC, sIL2R, IL-2RA) was first described as being actively released by activated peripheral blood T-cells via proteolytic cleavage of the cell surface IL-2R³.
If you want to learn more about sIL-2R and its use in the laboratory click on the picture below to watch a webinar with Dr. Bob Meek, St. Antonius Hospital.
For concrete data please consult the Instruction for Use in the download box on the top right side.
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