Periostin, also known as Osteoblast-specific factor 2 (OSF-2), is an extracellular matrix protein of approximately 90 kDa belonging to the fasciclin family¹. Periostin protein is composed of a cystein-rich region (EM!) and a four-coiled fasciclin-like repeats region (FASO). Type I collagen and fibronectin have been found to bind to the EMJ domain, Tenascin-C to the FAS1 domain². Periostin is upregulated by stimulation with Th2 cytokines (IL-4. IL-13)³. The periostin level correlates with both Th2-inflammation and fibrosis⁴.
The concentration of periostin in biological samples is increased in many diseases including atopic dermatitis, asthma, scleroderma, cholangiocellular carcinoma and diabetic retinopathy⁵-⁹. It has also been suggested that periostin may serve as a companion diagnostic marker for asthma therapeutics¹⁰.
It was originally identified in cells from the mesenchymal lineage, inducing a vicious cycle in the IL-4/Il-13 pathway. 
Fig. 1 Periostin as an inducer of a vicious cycle in the IL-4/Il-13 release
This ELISA kit specifically measures natural and recombinant human periostin. It does not react with either β ig-h3 or mouse periostin.
distributed by TECAN-IBL International
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