MuSK-Ab ELISA
- Regulatory Status
- RUO
- Kit size
- 12 x 8
- Method
- ELISA
- Incubation time
- 3 x 1h, 1 x 30 min
- Standard range
- 0 - 12 U/ml
- Specimen / Volumes
- 10µl serum
- Substrate / isotope
- PNPP 405 nm
Enzyme immunoassay for the qualitative and quantitative determination of autoantibodies against muscle-specific receptor tyrosine kinase (MuSK) in human serum.
MuSK (muscle-specific receptor tyrosine kinase) is part of an agrin receptor complex and mediates the agrin-induced clustering of acetylcholine receptors during synapse formation, and is also expressed at the mature neuromuscular junction (NMJ).
For concrete data please consult the Instruction for Use in the download box on the top right side.
[1] Berrih-Aknin, S., & Le Panse, R. (2014). Myasthenia gravis : a comprehensive review of immune dysregulation and etiological mechanisms. Journal of autoimmunity, 52, 90-100.
[2] El-Salem, K., Yassin, A., Al-Hayk, K., Yahya, S., Al-Shorafat, D., & Dahbour, S. S. (2014). Treatment of MuSK-associated Myasthenia gravis . Current treatment options in neurology, 16(4), 283.
[3] Thomas, L. (2012). Labor und Diagnose: Indikation und Bewertung von Laborbefunden für die medizinische Diagnostik, Frankfurt/Main: Th-Books Verl. 1786-1798.
[4] Huda, S., Woodhall, M. R., Vincent, A., & Heckmann, J. M. (2016). Characteristics Of acetylcholine‐receptor‐antibody–negative Myasthenia gravis in a South African cohort. Muscle & nerve, 54(6), 1023-1029.
[5] Romi, F., Aarli, J. A., & Gilhus, N. E. (2005). Seronegative Myasthenia gravis : disease severity and prognosis. European Journal of Neurology, 12(6), 413-418.
[6] Bokoliya, Suresh C., et al. "Anti-AChR, MuSK, and LRP4 antibodies coexistence: A rare and distinct subtype of Myasthenia gravis from Indian subcontinent." Clinica Chimica Acta 486 (2018): 34-35.
[7] Hoch, W., McConville, J., Helms, S., Newsom-Davis, J., Melms, A., & Vincent, A. (2001). Auto-antibodies to the receptor tyrosine kinase MuSK in patients with Myasthenia gravis without acetylcholine receptor antibodies. Nature medicine, 7(3), 365-368.
[8] Bartoccioni, E., Scuderi, F., Minicuci, G. M., Marino, M., Ciaraffa, F., & Evoli, A. (2006). Anti-MuSK antibodies: correlation with Myasthenia gravis severity. Neurology, 67(3), 505-507.
[9] Poulas, K., Koutsouraki, E., Kordas, G., Kokla, A., & Tzartos, S. J. (2012). Anti-MuSK-and anti-AChR-positive Myasthenia gravis induced by d-penicillamine. Journal of Neuroimmunology, 250(1-2), 94-98.
[10] Gilhus, N. E., Skeie, G. O., Romi, F., Lazaridis, K., Zisimopoulou, P., & Tzartos, S. (2016). Myasthenia gravis—autoantibody characteristics and their implications for therapy. Nature reviews neurology, 12(5), 259-268.]
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Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
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