Anti-Human CD109 (461) Rabbit IgG

CD109 is a glycosyl-phosphatidyl-inositol (GPI) - anchored glycoprotein sized about 180 - 190 kDa. It has been shown that CD109 is expressed in vascular endothelial cells, some epithelial cells, activated T-cells and platelets, and a subset of CD34+ megakaryocytic leukemia cells. The CD109 molecules are strongly expressed in KG1a cells, while CD34+CD109+ cells in fetal bone marrow include almost all myelocytic, erythroblastic and megakaryocytic precursor cells. For this reason, CD109 is considered to be a marker of megakaryocytic hematopoiesis in early stage. Furthermore, CD109 is considered to be different from existing activation markers of leukocytes and platelets, because of its structure and serological features. By reports of Takahashi et al., CD109 is significantly over expressed in squamous cell carcinoma of lung tissue, esophageal tissue and uterine cervical tissue. Thus, it is attracting attention in studying squamous cell carcinoma. Additionally, a recent study suggests that CD109 is involved in the regulation of transforming growth factor (TGF)-β signaling in some cancer cells and keratinocytes. Distributed by IBL International