VEGF-C ELISA

VEGF (vascular endothelial growth factor) is a highly specific growth factor in vascular endothelial cells that was discovered in the culture supernatant of a cell line derived from the anterior lobe of the human pituitary gland, and the results of gene analyses have shown that it is the same as VPF (vascular permeability factor), which was discovered at the same time. VEGF stimulates all steps in angiogenesis, including an increase in the proliferation, migration, and protease activity of cultured vascular endothelial cells, and the formation of blood-vessel−like structures in collagen gel, and it stimulates angiogenesis and vascular permeability in vivo as well. Since it is produced and secreted by many tumor cells, and its receptor is chiefly expressed by vascular endothelial cells, it is thought to be associated with tumor angiogenesis. As a result, VEGF has come to be known as an important modulator of blood vessel formation in the embryo and of angiogenesis in adult tissue. In contrast to VEGF, VEGF-C, which was discovered as a VEGF-associated molecule. It has been identified as a molecule stimulating lymph vessel formation through VEGFR-3, its specific lymphatic endothelium receptor. VEGF-C proteolytic processing produces several post-translational mature modifications. Please note, that this product is incapable of measuring the mature "p21 homo dimer VEGF-C".