sAPP-beta Swedish Type HS ELISA

This kit can measure human soluble APPβ swedish type (sAPPβ-sw) in biological samples. It is known that Amyloid-β, which is the major constituent of senile plaques, is produced from Amyloid-β Precursor Protein (APP), which exists in three main isoforms, namely APP695, APP751, and APP770, by the β-secretase (BACE1) and subsequently the γ-secretase. The production of soluble APPβ (sAPPβ) by β-secretase cleavage is the first step in APP processing. Furthermore, it is has been shown that a specific APP gene mutation exists in individuals who suffer early-onset familial Alzheimer’s disease, which is called Swedish mutation. This gene mutation, is a double mutation at positions -1 to -2 from the β-secretase cleavage site (Lysine670→Asparagine and Methionine671→Leucine). The Swedish mutation will lead to elevated Aβ40 and Aβ42 production, and therefore this mutation is utilized in establishment of transgenic mice. Measuring sAPPβ in Swedish type as well as in Wildtype is useful for research of AD. Separate control set available on request