Anti-Human Adiponectin Receptor 1 Rabbit IgG

In addition to serving as a place for energy storage, it has been shown that mast cells can also secrete various bioactive substances (adipokines). Adiponectin has been shown to be one of the adipokines possessing anti-diabetic, anti-atherosclerotic and anti-inflammatory actions. It is known that blood adiponectin levels are reduced in cases of obesity. As a result, adiponectin has been attracting close attention as a factor playing a central role in the development of metabolic syndrome. More recently, adiponectin receptors, Adiponectin Receptor 1 (AdipoR1) and Adiponectin Receptor 2 (AdipoR2) have been identified, inviting very close attention. AdipoR1 is expressed throughout the living body, but most prominently in skeletal muscles. Unlike the G-protein- coupled receptors (GPCR) reported previously, AdipoR1 can be topologically characterized by an intracellular N-terminal and extracellular C-terminal. Structurally, this receptor seems to belong to a new family of receptors different from the GPCR. AdipoR1 serves as a receptor for globular adiponectin and full-length adiponectin. It has been shown that this receptor transmits signals for suppression of glycogenesis and stimulation of fat burning and sugar utilization through activation of AMP kinase, p36MAPK and PPARα. Measurement of AdipoR1 is expected to be useful in not only diabetes-related research, but also research on inflammation, atherosclerosis and, as has been shown more recently, tumors.

Literature references

1. Sluch VM, Banks A, Li H, Crowley MA, Davis V, Xiang C, Yang J, Demirs JT, Vrouvlianis J, Leehy B, Hanks S, Hyman AM, Aranda J, Chang B, Bigelow CE, Rice DS.
   . ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse.
   Sci Rep. 2018 Sep 25;8(1):14339.
   PubMed ID: 30254279
   Keywords: retinal degeneration, eye tissue, brain tissue, retinoid metabolism