Anti-human CD109 (11H3) Mouse IgG

CD109 is a glycosyl-phosphatidyl-inositol (GPI) - anchored glycoprotein about 180 - 190 kDa size. It is shown that CD109 is expressed in vascular endothelial cells, some epithelial cells, activated T-cells and platelets, and subset of CD34+ megakaryocytic leukemia cells. The CD109 molecules are strongly expressed in KG1a cells, while CD34+CD109+ cells in fetal bone marrow include almost all myelocytic, erythroblastic and megakaryocytic precursor cells. For this reason, CD109 is considered to be a marker of megakaryocytic hematopoiesis in early stage. And CD109 is considered different from existing activation markers of leukocytes and platelets, because of its structure and serological features. By reports of Takahashi et al., CD109 is significantly over expressed in squamous cell carcinomas such as lung carcinoma, esophageal carcinoma and uterine cervical carcinoma. Thus, it is attracting attention for studying squamous cell carcinomas. Additionally, a recent study suggests that CD109 is involved in the regulation of transforming growth factor (TGF)-β signaling in some cancer cells and keratinocytes.