CD30 ELISA

Formerly sold as BE59151. Characterization of the CD30 antigen has shown it to be in its mature form a transmembrane protein of about 120kDa elaborated from an 84kD cytoplasmic precursor primarily through glycosylation. Interactions of the cytokine receptor CD30 with its ligand induces pleiotropic biologic effects, such as differentiation, activation, proliferation and cell death. CD30 furthermore seems to be involved in the control of the CD40/CD40L signal, T-cell proliferation and B-cell maturation induced by T-cell cytokines. Thus, CD30 seems to transmit information that is essential for the immune response. There is growing evidence for a potential role of the CD30 molecule in clinical use and therapy. An 85kDa soluble form of the CD30 molecule (sCD30) has been shown to be released by CD30+ cell in vitro and in vivo. It is probably derived from the 120kDa membrane bound molecule by proteolytic cleavage. Serum sCD30 detection can be regarded as a marker of the amount of CD30+ cells present in the body. Increased serum levels of sCD30 have been reported for patients with CD30+ ALCL and CD30+ embryonal carcinoma of the testis and were found to correlate with the clinical phase of the disease, i.e. presentation complete remission (CR), relapse. Elevated serum values of sCD30 are shown in the majority of patients with Hodgkin's Disease which again correlate with the presence of B symptoms and with the stage of the disease, i.e. tumor burden. While elevations of the soluble CD30 in serum of patients affected by infections diseases usually are not detected, infectious mononucleosis is a notable exception. Serum levels of sCD30 are also increased in most patients with HBsAg-positive chronic hepatitis and signs of active HBV replication, thus there is association of the raised sCD30 levels with the active phase of the illness. Abnormal soluble CD30 serum accumulation has been reported in Omenn's syndrome, a severe immunodeficiency. High elevations of sCD30 levels are found in patients of systemic lupus erythematosus which correlate with disease activity, in patients with the autoimmune liver disease primary biliary cirrhosis and in patients with rheumatoid arthritis. Synonyms: Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Lymphocyte activation antigen CD30, KI-1 antigen, CD antigen CD30