ICAM-1 ELISA

Formerly sold as BE59011. Intercellular Adhesion Molecule-1 (ICAM-1) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1), an alpha-betacomplex that is a member of the leukocyte integrin family of cell-cell and cell-matrix receptors. This family consists of the leukocyte adhesion glycoproteins LFA-1 which mediates lymphocyte adhesion, Mac-1 which mediates granulocyte adhesion and p150,95. ICAM-1 is a single-chain glycoprotein with a polypeptide core of 55kD. The role of ICAM-1 as a disease marker has been demonstrated for a number of different indications and pathological situations. ICAM-1 upregulation is detected in allergic disorders (airway inflammation, allergic contact dermatitis), cancer (GI-cancer, lymphoid malignancies, malignant melanoma), Infectious Disease (HIV-1, malaria tropica, hepatitis B), transplant rejection (transplanted heart, transplanted kidney, liver transplants), diabetes mellitus, myocardial infarction, glomerulonephritis, inflammatory process within the central nervous system, rheumatoid arthritis and psoriasis. Synonyms: Intercellular adhesion molecule 1, Major group rhinovirus receptor, CD antigen CD54