Interleukin-1alpha (IL-1a) ELISA

Formerly sold as BE51001. The interleukin-1 (IL-1) species represent an important family of biologically active mono nuclear cell-derived proteins which are involved in inflammatory reactions and in immune responses. Two distinct human IL-1 species, IL-1alpha and IL-1beta, have been identified. They share similarities such as the same molecular weight, similar biological effects and the same receptors on target cells. Their biological properties include pyrogenicity, bone resorption, presentation of antigen to T cells and stimulation of B and T lymphocyte proliferation. Elevated serum or blood levels of IL-1alpha have been found in patients with total hip replacement/ arthroplasties, in patients with recently diagnosted IDDM, in case of several carcinomas such as head and neck cancer, pancreatic cancer and thyroid cancer, in experimental acute pyelonephritis, in acute viral hepatitis and in septic shock. Both elevations in serum levels and joint fluids (synovial fluids) are detected in rheumatoid arthritis. IL-1alpha elevation is a marker for dental diseases such as pulpal inflammation and infections of the root canals. Significantly elevated concentrations in gingival crevicular fluid in subjects with peridantitis are detected. Urinary levels of IL-1alpha correspond to disease and therapy response in bladder cancer. Synonyms: Hematopoietin-1