Angiopoietin-like 8 ELISA

Original article #27795. Angiopoietin-like protein 8 (ANGPTL 8) consists of 198 amino acids and is secreted mainly from liver and fatty tissue. It has been also known as Betatrophin, Lipasin, refeeding induced fat and liver (RIFL) and TD 26. It is classified as an atypical ANGPTL family member as ANGPTL8 is highly homologous with the N-terminal domain of ANGPTL3 and ANGPTL4 although it does not have a C-terminal fibrinogen-like domain which is common to the ANGPTL family. Is has been observed that triglycerides levels become lower in plasma samples of ANGPTL8 deficient mice compared to the levels in wild type mice after feeding while it has been reported that triglycerides levels in plasma samples is elevated only if ANGPTL8 is overexpressed in presence of ANGPTL3. It has been considered that it becomes a target molecule for improving current drugs of hyperlipidemia or as a biomarker of metabolic diseases as ANGPTL8 is a lipoprotein regulatory factor that inhibits LPL activity through activation of ANGPTL3. This ELISA kit can measure full length of ANGPTL8 in human samples. Distributed by IBL International