Endothelial Lipase C-Term. ELISA

"Original article #27263 Endothelial Lipase (EL) is a metabolic enzyme of High Density Lipoprotein (HDL). It is a phospholipase A1 molecule that has high substrate specificity for a phospholipid that exists in HDL molecule and it promotes HDL metabolism by metabolizing this HDL phospholipid.  It has been considered that EL is involved in lipid metabolism and elevates the risk of arteriosclerosis as strong expression of EL on newly formed vessels and macrophages in arteriosclerotic lesions are observed, while EL expresses in vascular endothelial cells and vascular smooth myocytes of normal blood vessels.  It has been reported that both full length EL (active form) and cleaved EL (inactive forms, 40K fragment cleaved at N terminal and 28K fragment cleaved at C terminal cleaved by proprotein convertase) exist in blood. This ELISA kit is designed using two antibodies that detects C terminal fragments that can detect both full length EL and cleaved form EL that is cleaved at C-terminal in serum and EDTA-plasma regardless with or without administration of heparin injection that is conventionally required for the measurement."