Anti-human Daple Rabbit IgG

"Original article #28147 The canonical (β-catenin dependent) and non-canonical (β-catenin non-dependent) Wnt signaling pathways are signal pathways that regulate formation and maintainance of embryonic growth or cell structures of organs and amplification of cells. It is also involved in various diseases including cancers. It has been well known that the non-canonical Wnt signaling pathway regulates polarity determination of tissues and migration of cells. It has been revealed that the scaffold molecules “Dishevelled (Dvl)” and low molecular weight GTPase “Rho molecular group (Rac, Rho)” have essential roles in this pathway. Daple is a molecule that was identified by A. Kikuchi et al, Osaka University and they showed that it has a homologous sequence with Girdin or Gipie. It is suggested that Daple binds to Dvl and controls activation of Rac dependend on Wnt5a stimulus via its mutual interaction. It was discovered that Daple is essential for cell migration and restructuring of actin structure and its molecular mechanism has also an important role for healing of wound of skin by Daple knockout mouse analysis."