MPO Ab (p-ANCA) ELISA
- Regulatory Status
- EU: CE
- Kit size
- 12 x 8
- Method
- ELISA
- Incubation time
- 3 x 30 min
- Standard range
- 0 - 100 U/mL, cut-off 11 U/mL
- Specimen / Volumes
- 10 µL serum, plasma
- Substrate / isotope
- TMB 450 nm
Enzyme immunoassay for the qualitative and quantitative determination of IgG antibodies against myeloperoxidase (MPO) in human serum or plasma (EDTA, citrate, heparin). Anti-neutrophil cytoplasmic antibodies (ANCA), originally identified by immunofluorescence assays (IFA), are directed against cytoplasmic components of neutrophil granulocytes and monocytes. They have proven to be a useful serologic marker for a number of systemic, autoimmune mediated vasculitides. A perinuclear (p-ANCA) staining pattern of the neutrophil substrate is indicative for autoantibodies against myeloperoxidase (MPO), a 145 kDa large, cationic, covalently linked alpha2-beta2 complex. MPO autoantibodies are most closely associated with one form or another of microscopic polyangitis. They also occur in patients with polyangitis overlap syndrome without renal involvement, idiopathic or vasculitisassociated crescentic glomerulonephritis, classic polyarteritis nodosa and Churg-Strauss syndrome. The titer of MPO antibodies was found to reflect flares and remissions of these diseases in individual patients.
For concrete data please consult the Instruction for Use in the download box on the top right side.
Our Product Families
Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms, such as the Freedom EVOlyzer or Thunderbolt®.
All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use.
All of our assays have been designed and manufactured to meet the highest global regulatory requirements and quality standards. Tecan is certified under ISO 9001:2015, ISO 13485:2016 and is audited by a notified body according to Medical Device Single Audit Program (MDSAP).
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As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.
Our range of high-quality immunoassays is supported by a diverse portfolio of automated solutions, making us the perfect partner for you and your customers.
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