Anti-Human RIG-I (CTD) Rabbit IgG

This antibody was raised against the c-terminal domain of human RIG-I. RIG-I (retinoic acid inducible gene-I) is a cytoplasmic viral sensor, that has a RNA helicase domain and it is believed to recognize virus-derived double-stranded RNA (dsRNA). It is considered that RIG-I normally exists as an inactive form in the cytoplasm and turns to an active form when it recognizes dsRNA produced as a by-product of viral replication. It is thought that the active form of RIG-I exposes a signaling domain called CARD (caspase recruitment domain) which is normally hidden by steric hindrance. Downstream signaling then is activated by multimerization and interaction of CARD with IPS-1 expressed on mitochondria, eventually inducing the activation of interferon gene. Thus, RIG-I is believed to play an important role in viral infection-induced signaling. This antibody recognizes CTD (C terminal domain) of RIG-I and is able to detect RIG-I localized in avSGs (antiviral stress granules) that are genesis-induced in virus-infected cells. Distributed by IBL International