Anti-Rat RGMa Rabbit IgG (Frozen)
- Quantity / Tests
- 100 µg
- Species / Antigen
- rat
- Host
- Rabbit
- Subclass / Clone
- IgG
- Type
- Polyclonal
- Purification
- Affinity Purify
- Regulatory Status
- RUO
RGMa (Repulsive Guidance Molecule a) is a GIP-anchored protein, about 33 kDa, and it is implicated in axonal guidance and neural tube closure of embryonic retina. It has reported as a potent inhibitor of axonal regeneration in the adult central nervous system (CNS). It is speculated that RGMa inhibits neurite outgrowth by activating the RhoA-Rho kinase signaling pathway in vitro. While, it has reported that, in a rat SCI (spinal cord injury) model, neurite outgrowth is enhanced by administration of anti-RGMa antibody to lesion site, resulting they are improved in mortor functional recovery. Thus function analysis of RGMa is attracting attention in a research field of axonal regeneration of CNS. This antibody detects rat RGMa and can be used for western blotting, immuno-precipitation and FACS analysis. And it is also reported that administration of the antibody to cerebellar granule cells of 6 - 8 days-old rat, in vitro, neutralizes RGMa-dependent inhibition of neurite outgrowth.
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