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α-Synuclein ELISA

Catalog no.JP27740
Regulatory Status
RUO
Kit size
12x8
Method
ELISA
Incubation time
1x18h, 1x1h, 1x30min
Standard range
0.16 - 100 ng/mL
Specimen / Volumes
25 µL serum, plasma, CSF, cell culture supernatant
Substrate / isotope
TMB 450 nm
instructions for use
  • English

    • α-Synuclein is a 14.5kDa, soluble protein, which consists of 140 amino-acid residues and it is known as an intrinsically disordered protein.　It is mainly expressed in cerebral neocortex, hippocampus, nigra, thalamus and metepencephalon. The majority of it exists in the presynaptic terminal and nucleus of neuron cells and it is considered to be involved in the signal regulatory system of the synaptic vesicle. α-Synuclein is the main structural component of Lewy bodies, which are inclusion bodies, that exist inside of neuron cells in neurodegenerative diseases called “Synucleinopathies” such as Parkinson's disease, dementia with Lewy body and multiple system atrophy. It is considered that excessive accumulation of α-Synuclein is the main cause of synucleinopathies due to induction of shedding of dopamine-producing cells. The concentration of α-Synuclein in human blood or human CSF can be quantitatively measured by this ELISA kit.

    For concrete data please consult the Instruction for Use in the download box on the top right side.

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    All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use. 

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