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Total sAPP high sensitive ELISA

Catalog no.JP27731
Regulatory Status
RUO
Kit size
96
Method
ELISA
Incubation time
overnight 4°C / 30 min 4°C / 30 min RT
Standard range
0.39 - 25 ng/mL
Specimen / Volumes
100 µL serum, EDTA plasma, CSF, cell culture supernatant
Substrate / isotope
TMB 450 nm

This kit can measure the total amount human soluble APP fragments in biological samples. It is known that Amyloid-β, which is the major constituent of senile plaques, is produced from Amyloid-β Precursor Protein (APP), which exists in three main isoforms, namely APP695, APP751, and APP770, by the β-secretase (BACE1) and subsequently the γ-secretase. The production of soluble APPβ (sAPPβ) by β-secretase cleavage is the first step in APP processing. Furthermore, it is has been shown that a specific APP gene mutation exists in individuals who suffer early-onset familial Alzheimer’s disease, which is called Swedish mutation. This gene mutation, is a double mutation at positions -1 to -2 from the β-secretase cleavage site (Lysine670→Asparagine and Methionine671→Leucine).

Our Product Families

Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.

And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms, such as the Freedom EVOlyzer or Thunderbolt®.

All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use. 

All of our assays have been designed and manufactured to meet the highest global regulatory requirements and quality standards. Tecan is certified under ISO 9001:2015, ISO 13485:2016 and is audited by a notified body according to Medical Device Single Audit Program (MDSAP).

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As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.

Our range of high-quality immunoassays is supported by a diverse portfolio of automated solutions, making us the perfect partner for you and your customers.

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