Amyloid-beta (1-40) (FL) ELISA

Previously sold as JP27718 Amyloid-beta (1-40) (FL) ELISA. Amyloid-β (1-40) High Sensitive ELISA (RE59781) and Amyloid-β (1-40) ELISA (RE59751) are both used to measure Aβ (1-40) with an intact N-terminal. The Amyloid-β (1-40) High Sensitive ELISA uses a monoclonal antibody as labeled antibody, whereas the Amyloid-β (1-40) ELISA uses a polyclonal antibody. The plaques which appear in the brains of Alzheimer's disease patients are mostly constituted by the Amyloid-β protein (Aβ). Aβ is a peptide which consists of 40 or 42 (43) amino acids, and reports show that this is cleaved from β- and γ-secretase from the amyloid precursor protein (APP). Reports have shown many variants of Aβ exist and are clarified into the culture supernatant from the APP cDNA transfected mouse neuroblastoma cell. Furthermore, in 1995, a dominant and differential deposition of distinct βamyloid peptide species, Aβ (N3pE), in senile plaques was found by Saido et al. This modified molecule, starting at the 3rd amino terminal residue, glutamate, was discovered to convert to pyroglutamate through intramolecular dehydration.