Amyloid-beta (1-38) (FL) ELISA

Previously sold as JP27717 Amyloid-beta (1-38) (FL) ELISA. This ELISA kit measures human Aβ (1-38) with complete N-terminus. The plaques which appear in the brains of Alzheimer's disease patients are mostly constituted by the Amyloidβ protein (Aβ). Aβ is a peptide which consists of 40 or 42 (43) amino acids, and reports show that it is cleaved by β- and γ-secretase from the amyloid precursor protein. It has been shown that many variants of Aβ exist. In 2001, Edward H. Koo et al. found that the secretion of Aβ42 decreased by the effect of nonsteroidal anti-inflammatory drugs (NSAIDs), and with this, the secretion of Aβ38 increased. NSAIDs are attracting attention as a γ- secretase modulation and then Aβ38 and Aβ42 have become important object molecules to be measured as indicators for the effect of NSAIDs. This ELISA kit can measure human Aβ (1-38) which held N terminal side completely.