Offline mode

Mouse/Rat sAPP-alpha ELISA

Catalog no.JP27419
Regulatory Status
RUO
Kit size
12x8
Method
ELISA
Incubation time
overnight 4°C / 60min 4°C / 30min RT
Standard range
4.1 - 260 pg/ml
Specimen / Volumes
100 µL cell serum, EDTA-plasma, culture medium, brain extract
Substrate / isotope
TMB 450 nm

This kit can measure mouse/rat sAPPα and therefore is a useful tool in preclinical animal model research. It is important to pay special attention to sample selection as this kit can also measure mouse/rat full length APP. The Amyloid-β Precursor Protein (APP) is cleaved by β-secretase and subsequently by γ-secretase to form Amyloid-β (Aβ). It is hypothesized that in the normal metabolic pathway of APP, the APP is first cleaved by an enzyme called α-secretase instead of the β-secretase, thus avoiding the formation of Amyloid-β. This process is called Ectodomain-Shedding. The endproduct of α-secretase cleavage, the soluble APPα (sAPPα) is thought to have neuroprotective instead of neurodegenerative function. In more recent research, it has been attempted to inhibit the β-secretase and to activate the α-secretase for treating AD.

Our Product Families

Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.

And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms, such as the Freedom EVOlyzer or Thunderbolt®.

All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use. 

All of our assays have been designed and manufactured to meet the highest global regulatory requirements and quality standards. Tecan is certified under ISO 9001:2015, ISO 13485:2016 and is audited by a notified body according to Medical Device Single Audit Program (MDSAP).

Image on background

This is who we are.

As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.

Our range of high-quality immunoassays is supported by a diverse portfolio of automated solutions, making us the perfect partner for you and your customers.

Happy to help.

At Tecan, we are driven to improve people’s lives and health.