Fibulin-5/DANCE ELISA
- Regulatory Status
- RUO
- Kit size
- 12x8
- Method
- ELISA
- Incubation time
- 1x1h, 2x30min
- Standard range
- 0.08 - 5.0 ng/mL
- Specimen / Volumes
- 100 µL EDTA plasma, cell culture supernatant
- Substrate / isotope
- TMB 450 nm
Fibulin-5 is a member of the fibulin family of proteins. It was identified as an integrin ligand expressed mainly in arteries during embryogenesis and was subsequently named Developmental Arteries and Neural Crest EGF-like (DANCE). Fibulin-5/DANCE is a secreted protein of 448 amino acids and 66kDa. It contains a RGD (arginine-glycine-asparticacid) motif in the N-terminal ragion and binds to integrins α5β1, αvβ3 and αvβ5. Fibulin-5 is essential for elastic fiber formation. It is also involved in the assembly of continuous elastin polymer and and promotes the interaction of microfibrils and elastin. It further stabilizes and organizes elastic fibers in the skin, lung and vasculature. The expression of Fibulin-5/DANCE mRNA is elevated in smooth muscle cell, fibroblasts and endothelial cells of injured vascular tissues.
Fibulin-5-deficient mice recapitulate human aging phenotypes, such as loose skin (cutis laxa), emphysematous lungs, and stiff ateries. It is known that destruction and degradation of elastic fibers directly cause many aging-related disorders. Disorganized elastic fibers were observed in the fibulin-5-deficient mice and indicating that fibulin-5/DANCE is an essential protein for elastogenesis.
This product is for research use only and not for use in clinical diagnostic procedures.
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