Free PSA ELISA
- Regulatory Status
- EU: CE
- Kit size
- 12 x 8
- Method
- ELISA
- Incubation time
- 1 x 1 h, 1 x 30 min
- Standard range
- 0.3 - 10 µg/L
- Specimen / Volumes
- 50 µL serum
- Substrate / isotope
- TMB 450 nm
| instructions for use |
|---|
PSA is a 32 kDa single chain glycoprotein serine protease with a chymotrypsin like specificity produced by the secretory epithelium of the prostate gland (1). PSA is normally secreted into the seminal fluid and plays a functional role in the cleavage of the seminal vesicle proteins and the liquefaction of the seminal coagulum. Only low levels of PSA are normally present in the blood stream, and increasing serum concentrations indicate prostatic pathology, including benign prostatic hyperplasia and cancer of the prostate. Determination of PSA is now widely used for detection and management of patients with prostatic cancer and considered as the superior serological marker for cancer of the prostate. PSA has been shown to form stable complexes with different antiproteases and the dominating portion of PSA in patient serum occurs in complex with a1-antichymotrypsin (PSA-ACT) (4). However there are large variations in the relation between Free PSA and PSA-ACT complex between different individuals. A number of studies have found that the proportion of Free PSA is higher in benign prostatic disease as compared to prostatic cancer (4, 5). The CanAg Free PSA EIA is an assay for specific determination of Free PSA without cross reactivity with PSAACT complex.
For concrete data please consult the Instruction for Use in the download box on the top right side.
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Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms, such as the Freedom EVOlyzer or Thunderbolt®.
All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use.
All of our assays have been designed and manufactured to meet the highest global regulatory requirements and quality standards. Tecan is certified under ISO 9001:2015, ISO 13485:2016 and is audited by a notified body according to Medical Device Single Audit Program (MDSAP).
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As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.
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