CRP (C- reactive protein) ELISA

Enzyme immunoassay for the in-vitro-diagnostic quantitative determination of C-Reactive protein in human serum and plasma. C-Reactive Protein (CRP) is an acute-phase protein, produced exclusively in the liver. CRP is present in the serum of normal persons at concentrations ranging up to 5mg/l. The protein is produced by the fetus and the neonate and it does not pass the placental barrier, as such it can be used for the early detection of neonatal sepsis. Because febrile phenoena, leukocyte count and erythrocyte sedimentation rate (ESR) are often misleading, investigators and clinicians now prefer a quantitative CRP determination as a marker for acute inflammation and tissue necrosis. Within 6 hours of an acute inflammatory challenge the CRP level starts to rise. Serum concentration of CRP increases significantly in cases of both infectious and non-infectious inflammation of tissue damage and necrosis and in the presence of malignant tumors. CRP is present in the active stages of inflammatory disorders. The CRP-level increases dramatically following microbial infections, and this may be particularly helpful for the diagnosis and monitoring of bacterial infections in neonates and other immunocompromised patients at risk. In children, CRP is useful for differential diagnosis of bacterial and viral meningitis.

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