CD40L high sensitive ELISA

Formerly sold as BE58941. This High Sensitivity ELISA enables the analysis of CD40 Ligand (CD40L) in low concentrations from serum, plasma, or cell culture samples. The High Sensitivity ELISA Kits offer accurate quantification below conventional ELISA limits. CD40 belongs to the TNF receptor superfamily and is a biochemical marker for the identification of activated platelets of patients with cardiovascular diseases (angina pectoris, infarction, stroke etc.) A key role of CD40/CD40 Ligand interactions in immune activation, particularly in T-cell dependent B cell responses is anticipated. CD40 Ligand is expressed on the surface of activated CD4+ T cells, basophils, and mast cells. Binding of CD40L to its receptor, CD40, on the surface of B cells stimulates B-cell proliferation, adhesion and differentiation. A soluble isoform of CD40L has been shown to exist in the circulation. This soluble molecule is a homotrimer of a 18kDa protein exhibiting full activity in B cell proliferation and differentiation assays, is able to rescue B cells from apoptosis and binds soluble CD40. CD40L is discussed in relation to a potential role in supporting B cell tumors and it has been discovered that the molecular defect in the X-linked Hyper-IgM-Syndrome is targeted to the CD40 L gene, it is functional involved in B cell hybridomas and chronic lymphocytic leukemia as well as several autoimmune diseases. Synonyms: CD 40 Ligand; TNF ligand superfamily member 5; TNF related activation protein; T cell antigen Gp39; CD154 antigen; hyper IgM syndrome