Anti-human Gd-IgA1 (KM55) Rat IgG

Galactose-deficient IgA1 (Gd-IgA1) attracts a lot of attentions as a critical effector molecule in the pathogenesis and progression of IgA nephropathy (IgAN) in recent studies. It has been suggested that several O-link glycans modified regions exist in the heavy chain hinge region of human IgA1 molecule andGd-IgA1 circulates in the blood stream of patients with the pathological condition of IgAN. The deposition of Gd-IgA1 in glomeruli is considered to be involved in IgAN (Multi-hit Hypothesis of Gd-IgA1). The measuring system using snail (Helix aspersa; HAA) lectin that is extracted from snail and Gd-IgA1 ELISA (Code: 27600 Gd-IgA1 (Galactose-deficient IgA1) Assay Kit using this antibody (KM55) have been used in numerous studies and it has been suggested that serum levels of Gd-IgA1 in patients with IgAN is significantly elevated compared to the levels of healthy subjects or patients with renal disease other than IgAN in such studies. In addition, this antibody (KM55) can detect Gd-IgA1 in tissue by IHC technique differently from the feature of HAA lectin and it has been revealed that Gd-IgA1 specicillay exists in glomeruli of the patients of IgAN from the studies using this antibody. It has been expected that clinical significance of Gd-IgA1 wil be revealed by further studies using this antibody."

Literature references

1. Yamasaki K, Suzuki H, Yasutake J, Yamazaki Y, Suzuki Y.
   Galactose-Deficient IgA1-Specific Antibody Recognizes GalNAc-Modified Unique Epitope on Hinge Region of IgA1.
   Monoclon Antib Immunodiagn Immunother. 2018 Dec;37(6):252-256.
   PubMed ID: 30570353
   Keywords: Unique epitope, KM55 mAb, IgA nephropathy, IgAN, renal biopsy, galactose-deficient IgA1 monoclonal antibody
2. Suzuki H
   Biomarkers for IgA nephropathy on the basis of multi-hit pathogenesis.
   Clin Exp Nephrol. 2019 Jan;23(1):26-31.
   PubMed ID: 29740706
   Keywords: KM55 mAb, IgA nephropathy, IgAN, renal biopsy, galactose-deficient IgA1 monoclonal antibody, immune complexes
3. Neufeld M, Molyneux K, Pappelbaum KI, Mayer-Hain S, von Hodenberg C, Ehrchen J, Barratt J, Suzuki Y, Sunderkötter C.
   . Galactose deficient IgA1 (GD-IgA1) in skin and serum from patients with skin-limited and systemic IgA Vasculitis.
   J Am Acad Dermatol. 2019 Mar 19. pii: S0190-9622(19)30443-8.
   PubMed ID: 30902725
   Keywords: skin biopsies, KM55-antibody, skin-limited and systemic IgA vasculitis, perivascular Gd-IgA deposition

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