IgG4 Food Screen 280

instructions for use	MSDS
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Food Intolerance

The Tecan Food Intolerance portfolio includes a comprehensive range of food screening assays, allowing laboratories to choose panels covering from 7 up to 280 food allergens. The table on the right side provides an overview of the allergens included in each assay.

Intended Use

Enzyme immunoassay for the simultaneous, quantitative measurement of food specific IgG antibodies against 280 allergens in human serum and plasma (EDTA, Citrate, Heparin).

Summary and Explanation

It is intended to use as a tool to support the diagnosis of patients presenting various clinical symptoms associated with food intolerances. Advantage of the test is a non-invasive, quantitative measurement of plasma or serum samples for several foodstuff or –mixes at once. It is to be carried out by laboratory qualified personnel experienced in the use of in vitro diagnostic methods only.

"Lucretius once said that one man’s food may be another man’s poison."

Individuals with allergies and other types of food sensitivities react adversely to certain foods and food ingredients that others can consume with no problems. Many different types of reactions are involved in these individual adverse reactions. Adverse food reactions may include IgE and non-IgE-mediated primary immunological sensitivities, non immunological intolerances (such as an enzyme deficiency or reactions to certain chemicals), as well as secondary sensitivities. Adverse immune reactions to foods which are not IgE mediated are often called food “intolerances.”

The absence of IgE does not make them any less real; instead, other immune mechanisms, such as IgG or IgG4 antibodies are involved. IgG or IgG4-mediated adverse reactions to food are characterized by less severe reactions, are much more common (affecting approx. 45 % of the population) and have delayed onset (2 to 72 hours) after ingestion of an offending substance. Avoiding ingestion of such food (exclusion or rotation diet) is the best treatment to decrease symptoms.

There are several evidences for the involvement of IgG or IgG4 in food „intolerances“ e.g.:

Allergic reactions may occur independently of antigen-specific IgE;

Subsequent decrease of IgG when the offending food is removed from the diet;

Specific serum IgG has been reported in cases of celiac disease, dermatitis, or atopic eczema, as well as in diseases with increased intestinal permeability, and inflammatory bowel disease (IBD).

This evidence leads to the recommendation that IgG or IgG4-specific testing should be considered in cases where the patient shows unclear and chronic disorders, and in cases where classical diagnostics show no evidence.

Overview of Allergens – Plate A

Code	Name	Name (latin)
f52	Pineapple	Ananas comosus
f62	Cauliflower, raw	Brassica oleracea var. Botrytis
f44	Strawberry	Fragaria vesca
f17	Hazelnut	Corylus avellana
f35	Potato	Solanum tuberosum
f24	Prawn (Great king shrimp)	Penaeus monodon
f121	Maize, corn	Zea mays
f126	Peppermint	Mentha piperita
f311	Brussels sprouts	Brassica oleracea var. Gemmifera
f38	Spinach	Spinacia oleracea
f16	Walnut	Juglans regia
s1	Anise	Pimpinella anisum
f182	Green sprouting broccoli	Brassica oleracea var. Italica
f13	Peanut	Arachis hypogaea
f21	Herring	Clupea harengus
f78	Casein	Bos primigenius f. taurus
f199	Milk, unboiled	Bos primigenius f. taurus
f171	Mackerel	Scomber scombrus
f53	Peach	Prunus persica
f325	Sheeps milk	Ovis aries
f40	Yellowfin tuna	Thunnus albacares
f15	White bean	Phaseolus vulgaris
f49	Apple	Malus domestica
f11	Buckwheat	Fagopyrum esculentum
f930	Rainbow trout	Oncorhynchus mykiss
f209	Raspberry	Rubus idaeus
f73	Cherry	Prunus avium
f265	Caraway	Carum carvi
f20	Almond	Prunus amygdalus
f122	Plum	Prunus domestica
s7	Pepper, black	Piper nigrum
s27	Common thyme	Thymus vulgaris
f4	Wheat	Triticum aestivum
f168	Apricot	Prunus armeniaca
f94	Cheese, Camembert	Bos primigenius f. taurus
f200	Gouda cheese	Bos primigenius f. taurus
f164	Millet	Panicum miliaceum
f84	Kiwi fruit	Actinidia deliciosa
f41	Salmon	Salmo salar
f91	Mango	Mangifera indica
f141	White mushroom (Button mushroom)	Agaricus bisporus
f26	Pork	Sus scrofa domestica
f25	Tomato	Lycopersicon esculentum
f300	Goat milk	Capra hircus
f45	Baker's yeast	Saccharomyces cerevisiae
f204	Cashew nut	Anacardium occidentale
f92	Shaddock	Citrus maxima
f83	Chicken	Gallus gallus domesticus
f47	Garlic	Allium sativum
f88	Lamb meat	Ovis ammon f. aries, Ovis aries (Ovis spp.)
s5	Nutmeg apple	Myristica fragrans
f188	Small radish	Raphanus sativus v. Sativus
f85	Celery	Apium graveolens
f50	Grape	Vitis vinifera
s8	Cinnamon	Cinnamomum verum
f29	Banana	Musa x paradisiaca
s14	Dill	Anethum graveolens
f950	Green bean (french)	Phaseolus vulgaris
f3	Cod fish	Gadus morhua
f163	Kohlrabi	Brassica oleracea var. gongylodes
f66	Leek	Allium porrum
f33	Orange	Citrus sinensis
f9	Rice	Oryza sativa
f89	Mustard seed	Sinapis alba
f143	Turkey meat	Meleagris gallopavo
f32	Lemon	Citrus limon
s11	Sweet basil	Ocimum basilicum
f158	Spelt	Triticum aestivum ssp. Spelta
f120	Cucumber	Cucumis sativus
f96	Camomille tea	Matricaria chamomillae
f36	Coconut	Cocos nucifera
f65	Lentil	Lens culinaris
f46	Bell pepper	Capsicum annuum
f27	Beef	Bos primigenius f. taurus
f14	Soy bean	Glycine max
s9	Vanilla	Vanilla planifolia
f197	Zucchini	Cucurbita pepo ssp. Pepo convar. Giromontiina
f30	Pear	Pyrus communis
f12	Pea	Pisum sativum
f7	Oat	Avena sativa
f31	Carrot	Daucus carota
f194	Lettuce	Lactuca sativa
f278	Laurel (Bay leaf)	Laurus nobilis
f86	Parsley	Petroselinum crispum
f5	Rye	Secale cereale
f132	Asparagus	Asparagus officinalis
f74	Hen egg	Gallus gallus domesticus
f48	Onion	Allium cepa

Overview of Allergens – Plate B

Code	Name	Name (latin)
f10	Sesame	Sesamum indicum
f152	Plaice	Pleuronectes platessa
f181	Avocado pear	Persea americana
f207	Blackberry	Rubus fruticosus
f233	Carp	Cyprinus carpio
f334	Hops	Humulus lupulus
f6	Barley	Hordeum vulgare
f804	Rabbit	Oryctolagus cuniculus
f837	Chicory	Cichorium intybus var. Foliosum
f876	Cream cheese	Bos primigenius f. taurus
le001	Glutamate
s22	Oregano	Origanum vulgare
f101	Swede	Brassica napus ssp. Rapifera
f156	Sunflower seeds	Helianthus annuus
f183	Chinese cabbage	Brassica rapa ssp. pekinensis
f208	Fig	Ficus carica
f267	Cardamom	Elettaria cardamomum
f34	Mandarine	Citrus reticulata
f64	Cress	Lepidium sativum
f811	Amaranth	Amaranthus caudatus
f839	Field lettuce (Lamb's lettuce)	Valerianella locusta
f90	Malt	Hordeum vulgare
le025	Agar
s23	Piment	Pimenta dioica
f103	Pecan nut	Carya illinoinensis
f162	Nectarine	Prunus persica var. nucipersica
f185	Endive	Cichorium endivia
f210	Red currant	Ribes rubrum
f271	Veal boiled	Bos primigenius f. taurus
f37	Blue mussel	Mytilus edulis
f69	Horseradish	Armoracia rusticana
f812	Olive, green	Olea europaea
f840	Chard	Beta vulgaris ssp. vulgaris var. Vulgaris
f947	Papaya	Carica papaya
m5	Candida Albicans	Candida albicans
s24	Rosemary	Rosmarinus officinalis
f144	Locust Bean Gum	Ceratonia siliqua
f166	Wild boar	Sus scrofa
f186	Florence fennel	Foeniculum vulgare var. Azoricum
f211	Lingonberry (Cranberry)	Vaccinium macrocarpon
f288	Broad bean	Vicia faba
f39	Cabbage	Brassica oleracea var capitata
f76	Alpha-lactalbumin	Bos primigenius f. taurus
f824	Aspartam	Aspartam
f842	Sugar melon	Cucumis melo var. Cantalupensis
f952	Pumpkin	Cucurbita pepo
s13	Coriander seed	Coriandrum sativum
s25	Common sage	Salvia officinalis
f145	Turbot	Scophthalmus maximus
f167	Roe deer	Capreolus capreolus
f187	Kale	Brassica oleracea var. sabellica
f214	Gooseberry	Ribes uva-crispa
f309	Chickpea	Cicer arietinum
f411	Salmon roe	Salmo salar
f77	Beta-lactoglobulin	Bos primigenius f. taurus
f827	Sweet lupine	Lupinus albus
f843	Chanterelle	Cantharellus cibarius
f955	Coffee	Coffea arabica
s15	Ginger	Zingiber officinale
s26	Chives	Allium schoenoprasum
f146	Grapefruit	Citrus paradisi
f170	Pike	Esox lucius
f19	Sweet chestnut	Castanea sativa
f215	Cowberry	Vaccinium vitis-idaea
f312	Roquette	Eruca sativa
f450	Brewer's yeast	Saccharomyces uvarum
f79	Gluten	Triticum aestivum
f829	Wild rice	Zizania aquatica
f848	Green tea	Camellia sinensis
f97	Cacao	Theobroma cacao
s19	Marjoram	Origanum majorana
s30	Cayenne pepper	Capsicum frutescens
f149	Aubergine (Eggplant)	Solanum melongena
f173	Pilchard (Sardine)	Sardina pilchardus
f191	Beet root	Beta vulgaris var. conditiva
f216	Pine nuts	Pinus pinea
f316	Rape seeds	Brassica napus
f56	Redfish (Perch)	Sebastes marinus
f80	Lobster	Homarus gammarus
f832	Goosefoot (quinoa)	Chenopodium quinoa
f855	Tea, Lime Blossom	Tilia platyphylla
f98	Flax seed	Linum usitatissimum
s2	Curry powder
s6	Hot paprika powder	Capsicum annuum
f151	Guar	Cyamopsis tetragonolobus
f18	Brazil nut	Bertholletia excelsa
f206	Blueberry	Vaccinium myrtillus
f222	Date	Phoenix dactylifera
f319	Artichoke	Cynara cardunculus
f58	Duck meat	Anas platyrhynchos domestica
f802	Alaska pollock	Theragra chalcogramma
f836	Honigpollen (Honey)	Honigpollen
f856	Maple syrup	Acer saccharum
f99	Black tea	Camellia sinensis
s21	Clove	Syzygium aromaticum
s804	Curcuma (Turmeric)	Curcuma longa

Overview of Allergens – Plate C

Code	Name	Name (latin)
f1	Hen egg white	Gallus gallus domesticus
f174	Sole	Solea solea
f195	Black salsify	Scorzonera hispanica
f217	Black currant	Ribes nigrum
f304	Turnip
f348	Chocolate white
f57	Goose meat	Anser anser domesticus
f810	Curd cheese	Bos primigenius f. taurus
f849	Paraguay tea	Ilex paraguariensis
f875	Mozzarella, cow	Bos primigenius f. taurus
f943	Litchi	Litchi chinensis
le024	Pectin
f124	Honey	mel
f175	Haddock	Melanogrammus aeglefinus
f196	Savoy cabbage	Brassica oleracea convar. capitata var. sabauda
f223	Molasses	Beta vulgaris
f306	Lime	Citrus aurantiifolia
f349	Chocolate dark	Theobroma cacao
f67	Ovalbumine	Gallus gallus domesticus
f818	Pistachio nut	Pistacia vera
f850	Sea buckthorn juice	Hippophae rhamnoides
f902	Halibut	Hippoglossus hippoglossus
f945	Carambole	Averrhoa carambola
le026	Carrageenan
f126	Peppermint tea	Mentha piperita
f176	Squid	Loligo spp.
f201	Parmesan	Bos primigenius f. taurus
f236	Cow whey	Bos primigenius f. taurus
f310	White radish	Raphanus sativus
f406	Aloe vera	Aloe vera
f68	Ovomucoid	Gallus gallus domesticus
f831	Kamut wheat	Triticum polonicum
f851	Mirabelle	Prunus domestica subsp. Syriaca
f912	Unripe spelt grain	Triticum spelta
f948	Passion fruit	Passiflora edulis
s1	Anis seed	Pimpinella anisum
f128	Grapevine snail	Helix spec.
f177	Oyster	Ostrea edulis
f202	Sheep milk cheese	Ovis aries
f241	Northern prawn	Pandalus borealis
f329	Water melon	Citrullus lanatus
f415	Caviar black	Acipenseridae
f681	Red Wine	Vino
f833	Mallow	Malva sylvestris
f854	Parsnip	Pastinaca sativa
f920	Tragacanth	Astragalus
f951	Bamboo shoots	Bambusiodeae
s12	Summer savory	Satureja hortensis
f130	Olive, black	Olea europaea
f178	Crayfish	Procambarus clarkii
f203	Goat milk cheese	Capra hircus
f272	Tarragon	Artemisia dracunculus
f331	Saffron	Crocus sativus
f471	Bear's garlic	Allium ursinum
f682	White Wine	Vino
f838	Stinging nettle	Urtica dioica
f858	Lemon balm	Melissa officinalis
f931	Hare	Lepus europaeus
f953	Sweet potato	Ipomoea batatas
s16	Chervil	Anthriscus cerefolium
f165	Poppy seed	Papaver somniferum
f180	Oyster mushroom	Pleurotus ostreatus
f205	Yoghurt	Bos primigenius f. taurus
f286	Mare's milk	Equus caballus
f342	Chocolate	Theobroma cacao
f481	Shallot	Allium ascalonicum
f71	Spiny lobster	Palinurus elephas
f845	Verbena	Aloysia citriodora
f863	Cream	Bos primigenius f. taurus
f936	Kelp	Saccharina japonica
f964	Liquorice	Glycyrrhiza glabra
s17	Chili pepper	Capsicum frutescens
f169	Horse meat	Equus caballus
f189	Red cabbage	Brassica oleracea capitata
f212	Rhubarb	Rheum rhabarbarum
f287	Red kidney bean	Phaseolus vulgaris
f345	Macadamia nut	Macadamia ternifolia
f491	Pomegranates	Punica granatum
f75	Hen egg yolk	Gallus gallus domesticus
f846	Boletus	Boletus edulis
f87	Honeydew melon	Cucumis melo var. inodorus
f940	Guava	Psidium guajava
fx163	Jalapeno pepper
s18	Lovage	Levisticum officinale
f172	Anchovy	Engraulis encrasicolus
f190	Edam cheese	Bos primigenius f. taurus
f213	Raisin	Vitis vinifera
f303	Romanesco broccoli
f347	Quince	Cydonia oblonga
f55	Eel	Anguilla anguilla
f803	Pikeperch	Sander lucioperca
f847	Rooibos tea	Aspalathus linearis
f873	Cheese, Emmentaler type	Bos primigenius f. taurus
f942	Persimmon (kaki fruit, sharon)	Diospyros kaki
le020	Gelatine
s800	Capers	Capparis spinosa