beta2-Glycoprotein 1 IgM ELISA
- Regulatory Status
- EU: CE
- Kit size
- 12x8
- Method
- ELISA
- Incubation time
- 3x30min
- Standard range
- 0 - 100 U/mL, cut - off 12 U/mL
- Specimen / Volumes
- 10 µL serum, plasma
- Substrate / isotope
- TMB 450 nm
Enzyme immunoassay for the qualitative and quantitative determination of IgM antibodies against ß2- glycoprotein 1 in human serum or plasma (EDTA, citrate, heparin). The anti-phospholipid syndrome (APS) is an autoimmune disorder which can comprise clinical conditions as venous and arterial thrombosis, thrombocytopenia, myocardial infarction, recurrent spontaneous abortion and neurological complications. Cardiolipin (CL) is the most common, negatively charged, acid phospholipid and autoantibodies to cardiolipin are characteristic of APS. Anti-cardiolipin autoantibodies are also present in some patients with SLE and related diseases which is typical for a secondary anti-phopholipid syndrome. Autoantibodies associated with APS are directed not only against CL and similar phospholipides but also against phospholipid/protein complexes. ß2-glycoprotein 1 (ß2-GP1; apolipoprotein H) has been identified as such a natural and essential co-antigen for CL-autoantibodies. It has been shown that ß2-GP1 autoantibodies are associated with a higher risk of thrombosis. Autoantibodies to ß2-GP1 also occur independently from those to cardiolipin.
For concrete data please consult the Instruction for Use in the download box on the top right side.
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Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
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