Pankreatisches Polypeptid RIA
- Regulatory Status
- EU: CE
- Kit size
- 100
- Method
- RIA (DAb)
- Incubation time
- 2 x 24 h, 1 x 1 h
- Standard range
- 6.25 - 200 pmol/L
- Specimen / Volumes
- 100 µL serum
- Substrate / isotope
- 125I < 28 kBq
| instructions for use |
|---|
Pancreatic polypeptide (PP) is synthesized as an amino-terminal moiety of a precursor peptide. PP isolated from pancreas has 36 amino acid residues with an amidated C-terminal tyrosine. PP is secreted by F-cells of the islets of Langerhans. PP is localized almost entirely in the pancreas although detectable levels throughout gastrointestinal tract have been reported. PP in human plasma is reported to exist in at least four different forms: PP 1-36, PP 3-36 and two unidentified forms. PP is released into plasma during stimulation of meal. The physiological role of PP includes inhibition of stimulated gastric and pancreatic exocrine secretions and augmentation of insulin inhibited hepatic glucose production. These actions of PP are mediated by specific receptors. Receptor binding studies have shown that the intact C-terminal tyrosine amide is necessary for biological activity.
For concrete data please consult the Instruction for Use in the download box on the top right side.
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