17-OH-Progesterone RIA (CT)
- Regulatory Status
- EU: CE
- Kit size
- 96
- Method
- RIA (CT)
- Incubation time
- 1 x 3 h
- Standard range
- 0.17 - 14 ng/mL
- Specimen / Volumes
- 25 µL serum, plasma
- Substrate / isotope
- 125I < 190 kBq
Intended Use
Radioimmunoassay for the quantitative determination of 17-OH-Progesterone in human serum and plasma.
Biological activities of 17-hydroxyprogesterone
17α-hydroxyprogesterone (17-OHP) is a C-21 steroid hormone (molecular weight 330.3) which is produced from 17α-hydroxypregnenolone in the adrenals and also in the ovaries, testes and placenta. 17-OHP is hydroxylated at positions 11 and 21 to produce cortisol via 11-deoxycortisol.
Clinical applications of 17α-hydroxyprogesterone determination
As a rule, serum or amniotic fluid 17-OHP dosages are relevant to diagnose congenital adrenal hyperplasia (CAH).
This CAH is due to a specific enzyme defect (six distinct enzyme deficiencies have been described). As a result of these deficiencies, ACTH increases and produces adrenal hyperplasia and the raise of many steroid precursors. But it is also very interesting to know the value of 17-OHP in patients with varicocele. (17-OHP and testosterone represent markers of Leydig cell function) and in ageing male patients to detect Benign Prostatic Hypertrophy (BPH) and carcinoma of the prostate (PCA) (plasma 17-OHP is significantly lower in PCA and BPH groups than in normal men). There are other domains for 17-OHP investigations as: male infertility, girls with peripubertal virilization, children with premature adrenache (in these cases, the values of 17-OHP are increased without or after ACTH stimulation)
For concrete data please consult the Instruction for Use in the download box on the top right side.
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