11-Desoxycortisol RIA (CT)
- Regulatory Status
- EU: CE
- Kit size
- 96
- Method
- RIA CT
- Incubation time
- 2.5 h 37°C
- Standard range
- 0.3 - 65 ng/mL
- Specimen / Volumes
- 25 µL Serum
- Substrate / isotope
- 125I < 105 kBq
Intended Use
Radioimmunoassay for the quantitative determination of 11-Desoxycortisol (11-DOC) in human serum.
11-Desoxycortisol (Compound S) is an intermediate steroid in the glucocorticoids biosynthesis. Precusor of the cortisol, it comes from 17-hyroxyprogesterone after action of the 11 beta hydroxylase. This parameter is interesting for the diagnosis and follow up of treatment in case of surrenal enzymatic deficiency in 11 beta hydroxylase which is responsible for congenital surrenal hyperplasia in children and hyperandrogenics in adult women.
Under hypothalamic-pituitary control via the Adrenocorticotropic hormone (ACTH), the secretion of 11-Desoxycortisol follows a nycthemeral variation: it reaches a maximum in the morning (around 8 a.m.) and a minimal during the night (between 0 to 4 a.m.).
The measure of the 11-Desoxycortisol can be performed in serum using immunological competition methods (RIA).
The metyrapone inhibits the 11 beta hydroxylase and the conversion of the 11-Desoxycortisol in cortisol.
The metyrapone test is an indicator of the ACTH reserve.
For concrete data please consult the Instruction for Use in the download box on the top right side.
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Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
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All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use.
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As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.
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