Lipoprotein Lp(a) ELISA
- Regulatory Status
- EU: CE
- Kit size
- 12 x 8
- Method
- ELISA
- Incubation time
- 1 x 1h, 1 x 15min
- Specimen / Volumes
- 25 µL serum, plasma
- Substrate / isotope
- TMB 450 nm
| instructions for use |
|---|
Lp(a) ELISA provides a method for the quantitative determination of human Lp(a) in serum or plasma.
Apolipoprotein(a), Apo(a), is a glycoprotein linked by disulphide bridges to apolipoprotein B in the Lp(a) particle. Apo(a) is formed by three different structural domains. One of the domains, called kringle 4, type 2, is present in multiple copies, the number of which varies and is genetically determined, giving rise to different sizes of Apo(a). Depending on the method used, six to 23 different isoforms of Apo(a) ranging from about 300 to 900 kD have been identified.
Most individuals have two Apo(a) isoforms, although in some subjects no Apo(a) band can be detected when analyzed in SDS-gel electrophoresis followed by immunoblotting.
Recently, much interest has been focused on Lp(a) since there is a lot of evidence that circulating levels represents an independent risk factor for coronary vascular disease. The Lp(a) level has been found to be an inherited risk factor for ischaemic heart disease. High Lp(a) levels have been demonstrated in familial hypercholesterolemia and its measurement may be clinically useful for risk prediction in these patients.
Distributed by IBL International.
For concrete data please consult the Instruction for Use in the download box on the top right side.
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