GLP-1 (active forms) ELISA

The gut hormone glucagon-like peptide-1 (GLP-1) is secreted in response to nutrient intake and plays an essential role in the regulation of glucose homeostasis. There are multiple forms of GLP-1, among which GLP-1(7-37) and GLP-1(7-36)NH2 are considered to be biologically active. Accurate measurement of both forms of active GLP-1 is not only important for understanding the physiological mechanisms of blood glucose regulation in healthy people and type 2 diabetes patients, but it is also of utmost importance for both clinical and preclinical studies of GLP-1 agonists and DPP4 inhibitors (e.g. Sitagliptin®, Saxagliptin®).

Among the currently available methods for measuring active GLP-1 peptides, immunoassays are greatly favored because of their sensitivity. However, most immunoassays still require an extraction step of active GLP-1 which is tedious and time-consuming.

To meet these needs, a reliable and user-friendly assay with a high sensitivity is essential due to low plasma levels of the active form GLP-1.

Advantages of our assay

• Sensitivity: 0.10 (pmol/L)
• Specificity:
  GLP-1 (7-36)NH2 : 100%
  GLP-1 (7-37): 100%
  Others < 0.32%
• Assay time: 2.5 hours
• No extraction needed

GLP-1 active forms ELISA without extraction

IBL International is happy to present the GLP-1 active forms ELISA without extraction for the reliable measurement of biologically active forms of GLP-1.

Our assay needs no extraction step and detects both forms of the active GLP-1 with high sensitivity.

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