Leptin high sensitive ELISA

The recessive obesity mutation, ob, identified in 1950, results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. Freidman’s group at the Rockefeller University originally identified the obesity gene that encodes for Leptin in 1994. Leptin is a 16 kDa secreted protein produced by the ob gene. Adipose tissue produces Leptin and releases it into the bloodstream. As fat deposits grow, blood Leptin levels tend to increase. It has been suggested that Leptin acts as a lipostat, increasing as fat gets deposited into adipocytes. It has also been found that the protein acts as a hormone instructing the brain to stop food consumption and to increase activity. Furthermore, it has been shown to signal and probably control the onset of puberty. In addition, a recent study shows that Leptin might act as a potent inhibitor of bone formation through central nervous system.