Rat N-ERC/Mesothelin ELISA
- Regulatory Status
- RUO
- Kit size
- 12 x 8
- Method
- ELISA
- Incubation time
- 1 x 1 h, 2 x 30 min
- Standard range
- 0.08 - 5 ng/mL
- Specimen / Volumes
- 100 µL serum, EDTA plasma, culture medium
- Substrate / isotope
- TMB 450 nm
ERC has been identified as a gene showing stronger expression in cancer-affected renal cell than in normal renal tissue in Eker rats (a rat model of renal cancer). The human homologue of the protein encoded by this gene is called MPF (megakaryocyte potentiating factor) or mesothelin. This protein is mainly detected in mesothelial cells, and its involvement in the development of mesothelioma has been suggested, making it a promising tumor marker. In humans, involvement of this protein has also been suggested in the development of
pancreatic, ovarian and pulmonary cancers, etc. The protein is expressed as a GPI anchor-type membranous protein (about 71 kDa in molecular weight), which is thought to be digested by a furin-like protease to yield fragments about 31 kDa and 40 kDa in size.
We have established a system for the assay of this protein, referring to the 31 kDa fragment as N-ERC/Mesothelin and 40 kDa fragment as C-ERC/Mesothelin. The kit, an ELISA kit designed for the determination of N-ERC/Mesothelin and is aimed at analyzing the expression of ERC in detail using tumor cell lines, serum and plasma.
Separate control set available on request
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