Angiopoietin-like 4 ELISA
- Regulatory Status
- RUO
- Kit size
- 12 x 8
- Method
- ELISA
- Incubation time
- 1 x 1h, 2 x 30min
- Standard range
- 23.44 - 1500 pg/mL
- Specimen / Volumes
- 100 µL serum, EDTA-plasma, cell culture media
- Substrate / isotope
- TMB 450 nm
Angiopoetin-like 4 (ANGPTL4) is a member of the angiopoietin/ANGPTL family. Human ANGPTL4 consists of 406 amino acids. Its protein structure is similar to the angiopoietins, with a signal peptide directing secretion, an N-terminal coiled-coil domain (CCD), a linker, and a C-terminal fibrinogen-like domain (FLD). Full-length ANGPTL4 is secreted by liver and adipose tissues and cleaved to generate circulating CCD and FLD fragments. ANGPTL4 plays important roles in lipid and glucose metabolism. It inhibits lipoprotein lipase (LPL) activity by breaking the dimer molecule, and elevates plasma TG level. Furthermore, a role has been shown in breast cancer metastasis to the lung via regulation of vascular integrity.
Both antibodies used in this ELISA recognize parts of the N-terminal of the human ANGPTL4 protein.
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