Amyloid-beta Oligomers ELISA

This assay can be used to measure Amyloid-β Oligomers that have at least two intact N-termini. Alzheimer's disease (AD) is a neurodegenerative disease, in which Amyloid beta (Aβ) peptides accumulate in the brain and the predominant symptom is a decline of cognitive functions. It has been generally hypothesized that Aβ forms the senile plaques and this denatures the neurons and develops the symptoms of the disease. (This is called the 'amyloid hypothesis'.) However, the 'oligomer hypothesis' is becoming more and more prominent nowadays and it is thought that the disease is developed by decline in cognitive function because these soluble Aβ oligomers, which are intermediate objects of the condensation process, cause strong synaptic injurious effects. It has been reported that when the Aβ oligomers, which are secreted from the cell or are extracted from AD patient's brain, are injected into rat brain, it causes synaptic dysfunction and study memory loss. Moreover, it is also actually observed that the Aβ oligomers are increasing in brains of AD patients compared with healthy individuals.