Cortisol Saliva Luminescence Immunoassay
- Regulatory Status
- EU: CE IVDR
- Kit size
- 12 x 8
- Method
- Luminescence Immunoassay
- Incubation time
- 1 x 3 h; 1 x 10 min
- Standard range
- 0.015 - 3.20 µg/dL
- Specimen / Volumes
- 20 µL Saliva
- Substrate / isotope
- Luminol
Cortisol Saliva Luminescence Immunoassay is IVDR certified!
The IBL International Cortisol Saliva Luminescence Immunoassay is intended for the in-vitro-diagnostic quantitative determination of Cortisol in human saliva and for use as an aid in the diagnosis and treatment of adrenal disorders.
This device is not intended for point-of-care settings.
Cortisol (also known as hydrocortisone, compound F) is the main glucocorticoid in humans and is produced in the zona fasciculata of the adrenal cortex. 90 % of the circulating cortisol are bound to corticoid binding globulin (CBG, Transcortin), ca. 7 % are bound to albumin and only 1–3 % are unbound. Only the latter part represents the active form of cortisol. The free cortisol is released in saliva and is excreted via the kidneys as a small part among the metabolites of cortisol. The level of free cortisol in blood regulates mainly its secretion in the adrenal cortex in a negative feedback mechanism via CRH (corticotropin releasing hormone) in the hypothalamic region and the ACTH in the pituitary gland, but it is also affected by different situations above all by stress. In humans there is a physiological fluctuation of cortisol achieving the highest level in the morning and the lowest during midnight. This fluctuation of cortisol plasma level is reflected in saliva normally with a peak in the first 90 minutes after wake up. The cortisol measurement is indicated in adrenal disorders. Due to the diurnal fluctuations of cortisol a salivary sample collection is an easy method without the stress of repeated venipunctures. Our New IBL Cortisol Saliva Luminescence Immunoassay is calibrated to the reference method of the LC-MS/MS and replaces the former product referenced RE62011. Please contact us if you should require any specific information! The Luminescence IA is also available in bulk format (10x96 tests), with the catalogue number RE62119.
*Product availability and regulatory status may vary across regions outside the EU depending on local country-specific registration. CE IVD under IVDR to be launched soon. Consult with your Tecan associate for further information.
For concrete data please consult the Instruction for Use in the download box on the top right side.
Further Readings:
- Spit-and-measure testing – identifying over-production of cortisol https://www.tecan.com/blog/testing-for-cortisol-in-saliva-could-transform-business-culture
- Taking the stress out of cortisol measurements https://www.tecan.com/tecan-journal/taking-the-stress-out-of-cortisol-measurements
- Stressing the importance of quality assays https://www.tecan.com/hubfs/Tecan_Journal/201502/22_23_Stressing_the_importance_of_quality_assays_022015.pdf
Our Product Families
Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms, such as the Freedom EVOlyzer or Thunderbolt®.
All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use.
All of our assays have been designed and manufactured to meet the highest global regulatory requirements and quality standards. Tecan is certified under ISO 9001:2015, ISO 13485:2016 and is audited by a notified body according to Medical Device Single Audit Program (MDSAP).
This is who we are.
As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.
Our range of high-quality immunoassays is supported by a diverse portfolio of automated solutions, making us the perfect partner for you and your customers.
Happy to help.
At Tecan, we are driven to improve people’s lives and health.