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Intended purpose
This LC-MS/MS kit is intended for the determination of free Metanephrines, Normetanephrines and 3-methoxytyramine (3-MT) in (EDTA) plasma. The components in this kit must be used as stated in the user manual.
Summary
The Free Metanephrines test in (EDTA) plasma measures three metabolites of the catecholamines epinephrine, norepinephrine and dopamine. These catecholamines are made in the adrenal gland to regulate the heartbeat, blood pressure and glucose concentrations. They can also be released in excess by rare tumors, such as pheochromocytomas and paragangliomas, on adrenal and extra-adrenal chromaffin tissue. The majority of these tumors release epinephrine and norepinephrine. Some rare tumors however excrete mostly, or sometimes solely, dopamine.
This is why all three the catecholamines are important to be determined when one of these tumors is suspected. There are however some difficulties with determining catecholamines, some tumors, for example, are biochemically silent or only periodically secrete these catecholamines making false negatives a possibility. False positives may also arise because of panic disorders or congestive heart failure. Their metabolites, metanephrine, normetanephrine and 3-methoxytyramine (3-MT) have superior diagnostic sensitivity and specificity compared to urinary and plasma catecholamines and so are recommended for the diagnosis of pheochromocytomas and paragangliomas.
Manufactured by Diagnotix; Distributed by Tecan, IBL International GmbH.
For concrete data please consult the Instruction for Use in the download box on the top right side.
For concrete data please consult the Instruction for Use in the download box on the top right side.
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