The sInterleukin-2-Receptor ELISA is intended for the quantitative determination of human soluble IL-2 receptor (sIL-2R) in serum and plasma (EDTA, citrate, heparin).
The sInterleukin-2-Receptor ELISA is a solid phase enzyme-linked immunosorbent assay (ELISA), based on the on the sandwich principle measured on an absorbance reader. The assay is semi-automated requiring general purpose laboratory instruments and consumables such as absorbance microplate reader/washer, vortexer and pipettes to execute the test.
The test kit is intended for manual use and can be adapted to different ELISA processors like EVOlyzer®.
The interleukin-2 receptor (IL-2R) is a monomeric, heterodimeric or -trimeric protein¹ expressed on the surface of certain immune cells like lymphocytes that binds and responds to a cytokine called IL-2². Interleukin-2 (IL-2) is a body own signaling molecule mainly produced by activated T-cells. It acts on different types of B- and T-cells via the Interleukin-2 Receptor. The functional Interleukin-2 Receptor consists either of two or three protein chains. The dimeric IL-2R consists of the IL-2Rβ (CD122) chain and the IL-2Rγ (CD132) that form an intermediate affinity receptor for IL-2. If the IL-2α (CD25) chain is incorporated into the receptor complex the IL-2R attains high affinity for IL-2¹.
In 1985 the soluble Interleukin-2 Receptor (sIL-2R, sCD25, sTAC, sIL2R, IL-2RA) was first described as being actively released by activated peripheral blood T-cells via proteolytic cleavage of the cell surface IL-2R³.
If you want to learn more about sIL-2R and its use in the laboratory click on the picture below to watch a webinar with Dr. Bob Meek, St. Antonius Hospital.
For concrete data please consult the Instruction for Use in the download box on the top right side.
Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms, such as the Freedom EVOlyzer or Thunderbolt®.
All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use.
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