EDN
- Regulatory Status
- EU: CE
- Kit size
- 12x8
- Method
- ELISA
- Incubation time
- 2x1h, 1x30min
- Standard range
- 7.8 - 500 ng/mL
- Specimen / Volumes
- 100 mg stool, 50 μl serum or plasma
- Substrate / isotope
- TMB 450 nm
| instructions for use |
|---|
The EDN ELISA Kit is intended for the quantitative determination of EDN (eosinophil derived neurotoxin) in stool, plasma, serum and urine. For in vitro diagnostic use only.
After activation eosinophil granulocytes are segregating the cationic glycoprotein EDN (eosinophil derived neurotoxin). This 18-21 kDa single stranded glycosylated protein is also known as EPX (eosinophil protein X). Together with ECP (eosinophil cationic protein) EDN belongs to the ribonuclease superfamily. However EDN has a 100-fold increased ribonuclease activity. It is neurotoxic but not cytotoxic. The activation of eosinophil granulocytes is important during inflammatory processes in allergic reactions. Thus EDN is a marker for eosinophile activation and degranulation.
The measurement of EDN in stool allows the detection of clinical or subclinical chronic inflammation in the gut. In patients with colitis ulcerosa and/or morbus crohn, the measurement of EDN gives information on the activity of the disease and the prediction of a recidive.
Applications:
- Differentiation of food allergy and food intolerance
- Monitoring of an elimination diet
- Inflammatory processes in the gut
- Intestinal parasitosis.
Distributed by IBL International GmbH.
For concrete data please consult the Instruction for Use in the download box on the top right side.
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Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
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