Dentin Matrix Protein 1 ELISA

"Original article #27261 Dentin Matrix Protein 1 (DMP1) is a constitutive protein in the extracellular matrix of osteocytes and it belongs to the Small Integrin-Binding Ligand, N-linked Glycoprotein (SIBLING) family. It is synthesized as a full-length 105kDa proprotein and is divided into a 37kDa N terminal protein fragment and a 57kDa C terminal protein fragment during the secretion process. It has a lot of acidic domains and it binds with calcium as it becomes negatively charged within tissues and it has an important role for bone mineralization. DMP1 expresses in osteocytes while other constitutive proteins in the extracellular matrix such as Osteopontin, Osteocalcin and Bone sialoprotein express in osteoblast cells. Osteocytes which are the main constituent cells of bone regulate activities of osteoclastic cells and osteoblast cells and it adjusts the bone remodeling process. They also act as endocrine cells, which secrete FGF-23. DMP1 in blood is considered as a candidate biomarker reflecting osteocyte activity and it is also suggested to add useful information for research of bone metabolism and phosphate metabolism. The concentration of DMP1 in human blood can be quantitatively measured by this ELISA kit."