Respiratory syncytial virus IgA ELISA

Enzyme immunoassay for the qualitative determination of IgA class antibodies against RSV in human serum or plasma (citrate, heparin). Respiratory syncytial virus (RSV) is a negative-sense, enveloped RNA virus and belongs to the family of paramyxoviridae. RSV infection is a disease of the respiratory tract with various characteristics. Infection of children causes serious bronchiolotis while adults get only mild infections of the upper respiratory system. Serious complications are frequently observed in special risk groups like premature infants, babies, older people and persons with chronicle diseases of the respiratory tract. Respiratory syncytial virus infects cells of the epithelia of the upper respiratory tract und causes necrosis by cell fusion, in combination with inflammatory exudates and blockage of the respiratory system in serious problems can occur. If the virus goes down to the lower respiratory tract formation of oedema and alveolar collapse are possible. The virus is spread all over the world and highly contagious. Most infants become infected with RSV in their first winter season; between 25% and 40% have signs or symptoms of bronchiolitis or pneumonia, and 0.5% to 2% require hospitalization. Most children will have serological evidence of RSV infection by 3 years of age. RSV also causes repeated infections throughout life, usually associated with moderate-to-severe cold-like symptoms.

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