Human IL-23 ELISA
- Regulatory Status
- RUO
- Incubation time
- 1 x 2 hr,1 x 30 min,1 x 20 min
- Kit size
- 12 x 8
- Specimen / Volumes
- 100 μL supernatants, buffered solutions, serum, plasma
- Standard range
- 156.25 - 5000 pg/mL
- Substrate / isotope
- TMB 450 nm
Intended use
The Human IL-23 ELISA kit is a solid phase sandwich ELISA for the in-vitro qualitative and quantitative determination of IL-23 in supernatants, buffered solutions or serum and plasma samples. This assay will recognise both natural and recombinant human IL-23. This kit has been configured for research use only. Not suitable for use in therapeutic procedures.
Summary
Interleukin-23 is a heterodimeric cytokine consisting in two subunits : p40, shared with IL-12 and a distinct one : the p19 (the IL-23 subunit). Although IL-12 activates naive T cells, the initial description of IL-23 was the preferential action on memory T cells to increase IFNg production. In conjonction with IL-6 and TGF-β1, IL-23 is necessary to maintain the Th1 lineage. IL-23 plays an important role in the inflammatory response against infection, and is implicated in the developpement of cancerous tumors and auto immune diseases. Over expression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin.
- Aggarwal S., Biol Chem. 2003 Jan 17; 278 (3): 1910-4.
- Brombacher F., Trends Immunol. 2003 Apr; 24 (4): 207-12.
- Cordoba-Rodriguez R., Expert Opin Biol Ther. 2003 Aug; 3 (5): 715-23.
- Cua DJ., Nature. 2003 Feb 13; 421 (6924): 706-8.
- Frucht DM., Sci STKE. 2002 Jan 08; 2002 (114): PE1
- Holscher C., Med Microbiol Immunol (Berl). 2004 Feb; 193 (1): 1-17.
- Lankford CS., J Leukoc Biol. 2003 Jan; 73 (1): 49-56.
- Lee E., JEM. 2004 Jan 5; Volume 199 (1): 125-130.
- Vandenbroeck K., J Pharm Pharmacol. 2004 Feb; 56 (2): 145-60.
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Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms, such as the Freedom EVOlyzer or Thunderbolt®.
All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use.
All of our assays have been designed and manufactured to meet the highest global regulatory requirements and quality standards. Tecan is certified under ISO 9001:2015, ISO 13485:2016 and is audited by a notified body according to Medical Device Single Audit Program (MDSAP).
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As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.
Our range of high-quality immunoassays is supported by a diverse portfolio of automated solutions, making us the perfect partner for you and your customers.
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