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The Brain-derived Tau (BD-Tau) LUM is a sensitive and accessible research-use only blood assay. Combining a specific antibody targeting brain-derived Tau with upfront immunoprecipitation, BD-Tau LUM offers researchers a powerful and accessible tool to investigate Alzheimer's disease pathology, progression, and biomarker dynamics in plasma.
The Human BD Tau Luminescence Immunoassay is an enzyme immunoassay intended for the quantitative determination of brain derived TAU protein from peripheral cell free body fluids as blood plasma or serum after enrichment of BD Tau using the BD-Tau Neuro IP Kit (30260912).
The Tau protein is a microtubule-stabilizing protein being part of the axons of nerve cells in the central nervous system (CNS). Measuring total Tau in CSF reflects axonal destruction and has found its way into diagnostic criteria guidelines¹, but measuring total Tau in blood does not correlate with its corresponding CSF value. As 80% of Tau in blood originates from peripheral tissue, being able to selectively measure the brain-derived fraction will enhance specificity and accessibility of Tau as an AD biomarker. The antibody used in the BD-Tau LUM is targeting the brain-derived Tau isoform only.
The analysis of brain-derived Tau is coupled with a pre-analytical immunoprecipation (IP) step to enhance better detection in the later assay.
Using an assay to detect BD-Tau in blood samples provides a low-invasive research tool to help screen and stratify participants for different kinds of studies.
Distributed by TECAN, IBL international
For concrete data please consult the Instruction for Use in the download box on the top right side.
Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
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