NSE ELISA
- Regulatory Status
- EU: CE
- Kit size
- 12 x 8
- Method
- ELISA
- Incubation time
- 1 x 1 h, 1 x 30 min
- Standard range
- 7.5 - 138 µg/L
- Specimen / Volumes
- 25 µL serum
- Substrate / isotope
- TMB 405/620 nm
| instructions for use |
|---|
The glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase, EC 4. exists as several dimeric isoenzymes (aa, aß, a?, ßß and ??) composed of three distinct subunits a, ß and ?. The ? unit is found either in a homologous ??- or in a heterologous a?-isoenzyme and is known as neuron-specific enolase (NSE). The monoclonal antibodies used in the CanAg NSE EIA bind to the ?-subunit of the enzyme and thereby detects both the ?? and the a? forms (1, 2). The NSE levels are low in healthy subjects and subjects with benign diseases. Elevated levels are commonly found in patients with malignant tumours with neuroendocrine differentiation, especially small cell lung cancer (SCLC) (3) and neuroblastoma. Quantitative determination of NSE in serum may be valuable in the management of patients with suspected or diagnosed SCLC or neuroblastoma, to confirm the diagnosis, to monitor the effect of treatment and to aid in the detection of recurrent disease
For concrete data please consult the Instruction for Use in the download box on the top right side.
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Our comprehensive immunoassay portfolio includes a number of specialty diagnostic immunoassays for endocrinology, immunology and autoimmunity, as well as for diagnosis of multiple infectious diseases. We are pioneers and market leaders in saliva diagnostics, with over 40 years of experience supplying a broad portfolio of luminescence- and ELISA-based tests, including our highly acclaimed HMGB1 and MuSK-Ab ELISAs.
And as experts in laboratory automation, we can support our customers with the protocols for open ELISA platforms, such as the Freedom EVOlyzer or Thunderbolt®.
All products are only available for sale to laboratory professionals and may not be available in all countries. Availability and regulatory status may vary across regions depending on local country-specific registration. Please always read and follow the instructions for use.
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As part of the Tecan Group, we have a leading market position in diagnostics and research, with over 40 years of experience in the development, manufacture and supply of enzyme-, radiolabel- and luminescence-based immunoassays.
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